BEGIN:VCALENDAR VERSION:2.0 PRODID:-//jEvents 2.0 for Joomla//EN CALSCALE:GREGORIAN METHOD:PUBLISH BEGIN:VEVENT UID:38bae35f3849703ddc0bb7b921f0ec92 CATEGORIES:Colloquium CREATED:20210927T164610 SUMMARY:Professor Eva-Maria Strauch, University of Georgia DESCRIPTION:Targeting Viral Surface Glycoproteins \nViral surface glycoproteins provide a powerful way to train the immune system to be prepared for a given virus . Elegant studies have demonstrated how stabilization of these metastable p roteins can be undertaken. However, efforts were largely performed manually and step-by-step. We have incorporated several of these molecular strategi es into systematic automation protocols to stabilize viral surface proteins while paying close attention to their molecular functionalities. Using our approach, we have generated a stabilized version for instance for fusion p rotein of RSV, rivaling the clinical candidate. We can provide further prel iminary data on human metapneumovirus (hMPV) and SARS CoV-2 as model system s which both are otherwise highly instable. We will also shortly discuss po tential therapeutic approaches for treatment of viral infections through ta rgeting of intermediate states, as well as a new approach for the generatio n of protein-protein interactions using neural networks.\nHosted by Profess or Sagar Khare\nFor Zoom meeting information, please contact Loretta Lupo @ This email address is being protected from spambots. You need JavaScript e nabled to view it.\n \n X-ALT-DESC;FMTTYPE=text/html:
Target ing Viral Surface Glycoproteins
Viral surface glycoproteins provide a powerful way to train the immu ne system to be prepared for a given virus. Elegant studies have demonstrat ed how stabilization of these metastable proteins can be undertaken. Howeve r, efforts were largely performed manually and step-by-step. We have incorp orated several of these molecular strategies into systematic automation pro tocols to stabilize viral surface proteins while paying close attention to their molecular functionalities. Using our approach, we have generated a st abilized version for instance for fusion protein of RSV, rivaling the clini cal candidate. We can provide further preliminary data on human metapneumov irus (hMPV) and SARS CoV-2 as model systems which both are otherwise highly instable. We will also shortly discuss potential therapeutic approaches fo r treatment of viral infections through targeting of intermediate states, a s well as a new approach for the generation of protein-protein interactions using neural networks.
Hosted by Professor Sagar Khare
For Zoo
m meeting information, please contact Loretta Lupo @
DTSTAMP:20240329T153135 DTSTART:20211130T160000 DTEND:20211130T170000 SEQUENCE:0 TRANSP:OPAQUE END:VEVENT END:VCALENDAR