Bioorganic and organic reactivity is examined using analytical methods, including computational chemistry and mass spectrometry. Specific projects include the study of damaged DNA, carbene reactivity, and catalysis.
GPA: > 3.5
Course Experience: Ideally both semesters of organic though particularly strong students have started as early as freshman year
Current Undergraduate Researchers
- Uthman Qureshi
- Catherine Kratka
Publications with Undergraduate Co-authors
Michelson, A. Z.; Petronico, A. "2-Pyridone and Derivatives: Gas Phase Acidity, Proton Affinity, Tautomer Preference and Leaving Group Ability," J. Org. Chem., 2012, 77, 1623-1631.
Rozenberg, A; Lee, J. K. "Theoretical Studies of the Quinolinic Acid to Nicotinic Acid Mononucleotide Transformation," J. Org. Chem., 2008, 73, 9314-9319.
Pan, S.; Verhoeven, K.; Lee, J. K. "Investigation of the Initial Fragmentation of Oligodeoxynucleotides in a Quadrupole Ion Trap: Charge Level-Related Base Loss," J. Am. Soc. Mass Spectrom. 2005, 16, 1853-1865.
Schulze, S. M.; Santella, N.; Grabowski, J. J., Lee, J. K. "The Anionic Oxy-Cope Rearrangement: Using Chemical Reactivity to Reveal the Facile Isomerization of the Parent Substrates in the Gas Phase," J. Org. Chem. 2001, 66, 7247-7253.
Kiruba, G. S. M.; Xu, J.; Zelikson, V.; Lee, J. K. "Gas Phase Studies of Formamidopyrimidine Glycosylase (Fpg) Substrates," Chem. Eur. J., 2016, 22, 3881-3890 (special issue "Women in Chemistry": http://bit.ly/CEJ_Women2016).
Michelson, A. Z.; Rozenberg, A.; Tian, Y.; Sun, X.; Davis, J.; Francis, A. W.; O'Shea, V. L.; Halasyam, M.: Manlove, A. H.; David, S. S.; Lee, J. K. "Gas-Phase Studies of Substrates for the DNA Mismatch Repair Enzyme MutY," J. Am. Chem. Soc., 2012, 134, 19839-19850.